Tolerance induction might involve both the innate and the adaptive immune systems. Paracellular transport is blocked by the presence of tight junctions. Soluble proteins are taken up by fluid phase endocytosis and pursue a transcellular pathway endolysosomal pathway. Factors influencing intestinal uptake of food antigens. Cecilia Berin 8 In Vitro Diagnostic Methods in the Evaluation of Food Hypersensitivity, 110 Robert G. Am J Physiol Gastrointest Liver Physiol 2005;289: G890—7.
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. . Readers should consult with a specialist where appropriate. J Allergy Clin Immunol 2000;106:744—51. Fahrenholz 34 Food Colorings and Flavors, 411 Matthew J.
The human basophil: a new appreciation of its role in immune responses. The intestinal permeability test applied to the diagnosis of food allergy in paediatrics. It may reflect a combination of events. Cecilia Berin 8 In Vitro Diagnostic Methods in the Evaluation of Food Hypersensitivity, 110 Robert G. Allergic eosinophilic esophagitis and gastroenteritis Primary eosinophilic gastrointestinal disorders include eosinophilic esophagitis, gastritis, gastroenteritis, enteritis, and eosinophilic colitis.
Inflammatory bowel disease: Is the intestine a Trojan horse? Several groups looked at tolerance induction in manipulated animals to assess the need for M-cells in this process. Recombinant carp parvalbumin, the major cross-reactive fish allergen: a tool for diagnosis and therapy of fish allergy. Ideas of one author may sometimes differ from those of another, but in general there is remarkable agreement from chapter to chapter. Three competing concepts, which are not mutually exclusive, might explain humoral memory. Characterization of the major allergen of plum as a lipid transfer protein. Oral tolerance can be defined as the active, antigen-specific non-response to antigens administered orally. Omalizumab, antiIgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma.
Given the modest amounts present in the serum, it has been even more difficult to detect IgE in mucosal tissues or secretions. Sicherer 24 General Approach to Diagnosing Food Allergy and the Food Allergy Guidelines, 306 Jonathan O B. J Pediatr Gastroenterol Nutr 2000;30:S4—12. Histologic studies of endoscopic biopsy specimens in symptomatic patients reveal nonspecific markers of inflammation, which include prominent eosinophilia and plasma cells, crypt abscesses, and mild villous injury. Sicherer 26 Controversial Practices and Unproven Methods in Allergy, 328 David R.
Oral tolerance once induced suppresses T-cell allergic responses, the basis of most non-IgE-mediated food-allergic diseases. Parvalbumin, a cross-reactive fish allergen, contains IgE-binding epitopes sensitive to periodate treatment and Ca2+ depletion. The precise mechanisms implicated and the roles played in downregulating the mucosal immune responses, however, remain to be characterized. This provides a larger area for contact with luminal contents. Int Arch Allergy Immunol 2002;127:118—22.
Allan Bock and Hugh A. Plasma cells produce monomeric IgA or IgM that polymerizes after binding to J chain. The section on diagnosis of adverse reactions to foods constitutes a review of the approaches available for diagnosis; and their strengths and weaknesses. Considering the multiple biological effects of mast cell mediators, one can propose several possible functions of mast cells in vivo. Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods.
Is celiac disease an autoimmune disorder? Mucosal tolerance: a two-edged sword to prevent and treat autoimmune diseases. Am J Physiol Cell Physiol 2005;288:C1—19. The diagnosis is chiefly made by clinical symptoms and challenge testing, but may also be supported by resolution of symptoms after dietary elimination of the perpetrator protein. Int Arch Allergy Immunol 1999;119:247—58. Although no oral tolerance studies have been performed in these animals, the concept that controlled inflammation and oral tolerance are linked phenomena suggest that defects in tolerance would exist here as well. The 11S—12S globulins are found in the seeds of many monocotyledonous and dicotyledonous plants with homologs having been identified in gymnosperms including conifers.